Transcriptional Isoforms of NAD+ kinase regulate oxidative stress resistance and melanoma metastasis
Metastasizing cancer cells encounter a multitude of stresses throughout the metastatic cascade.Oxidative stress is known to be a major barrier for metastatic colonization, such that metastasizing cancer cells must rewire their CLEANSER SHAMPOO 6 metabolic pathways to increase their antioxidant capacity.NADPH is essential for regeneration of cellula